One thing as distinctive as every coin collector is how they utilize their 2x2 holders. Above is how I do it. The hinged part goes at the top, with staples along the other three sides. A seasoned dealer once told me never to staple too close to the coin since they can rust over time and affect the coin. Another tip, crunch down the rounded part of the staples with needle-nose pliers. It gives you more room in a stock box and eliminates unsightly protrusions against vinyl pages.
Labeling - for me, it's series and denom in upper left, date/MM upper right, condition lower right, and any imperfections or defects of note (cleaning, holes, scratches, etc) go in the lower left. On the reverse, along the top I put the date I acquired it and sometimes the price in the lower right.
I also like to "size-up" when housing by using a larger demon 2x2 than the coin. Nickels go in quarters holders, dimes and pennies go in nickel holders, etc. That way I can still see the edges.
I've seen some pretty creative and distinctive 2x2s at coin shows and LCSs over the years. Some sloppy ones too.
What's your style/preference?